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Further analysis is required to further identify the SRD molecules and the biological mechanism by which they mediate the toxicity associated with acute radiation sickness.
Tau, an important pathological protein of Alzheimer's disease (AD), can mediate the toxicity of amyloid β (Aβ).
The zebrafish (Danio rerio) has three identified AHRs: AHR1A and AHR1B, the roles of which are not yet well elucidated, and AHR2, which has been shown to mediate the toxicity of various anthropogenic compounds including dioxins, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs).
YbaJ serves to mediate the toxicity of Hha.
Both are markedly hyperosmotic, in the range of the complete KYWJ formulation, and their osmolality may mediate the toxicity.
Indeed, nitric oxide and hydroxyl radical formation has been reported to mediate the toxicity induced by MPP+ and rotenone.
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The brominated compounds appear to bind to the same cytosolic receptors believed to mediate the toxicities of the chlorinated analogs.
The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins -widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne.
Free radical formation in heme proteins is recognized as a factor in mediating the toxicity of many drugs.
The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs.
Western blotting further showed the gas plasma treatment degraded the A subunit, which mediates the toxicity of Stx.
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