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Exact(11)
This host-pathogen model should enable the identification of factors that mediate the switch from GI infection to systemic candidaemia.
12 The involvement of a specific miRNA, the miRNA-208, has also been shown to mediate the switch from MHCα to MHCβ isoform.
Herein, we observed that PERK modulates p38 phosphorylation that affects the target selection of ATF4 to mediate the switch between autophagy and apoptosis.
The finding that doxorubicin can bring about both outcomes, depending on dose, effectively rules out the notion that the DNA damage pathways themselves mediate the switch.
Changes in cell-to-cell signalling and interaction mediate the switch between epithelial and mesenchymal phenotypes and consequently dictate the receptivity towards signals from the extracellular milieu.
The absence of these growth factors in the synovial compartment of patients with self-limiting disease is not surprising, because one would not expect an expanded fibroblast layer (which would mediate the switch to persistence) in such patients.
Similar(49)
What mediates the switch from one type of society to another?
The finding that ecdysone signaling is involved in mediating the switch in the developmental response to starvation that occurs at the minimal viable weight [41], [42] suggests the possibility that in Drosophila starvation induces metamorphosis by enhancing ecdysone secretion.
AMPK, as a key regulator of energy metabolism, mediates the switch from anabolic processes to catabolic pathways.
mTOR acts as a major signaling hub, integrating multiple inputs and mediating the switch between growth and somatic maintenance to extend lifespan.
The results from the PPARα knockout and ChIP-Seq experiments in combination provide further support that PPARα is a key regulator that mediates the switch in metabolism from carbohydrates to fatty acids during torpor.
More suggestions(15)
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