Sentence examples for mediate the suppressive from inspiring English sources

These molecules are reported to act synergistically to mediate the suppressive effects of MSCs in the inflammatory microenvironment.

Overexpression of Egr-1 potentiated, whereas overexpression of Sp1 alleviated, the suppressive effect of IL-1 on the PPARγ promoter, suggesting that Egr-1 may mediate the suppressive effect of IL-1.

IL-1 inhibited the activity of PPARg promoter and overexpression of Egr-1 potentiated the inhibitory effect of IL-1, suggesting that Egr-1 may mediate the suppressive effect of IL-1.

It is noteworthy that these changes at the PPARγ promoter were concomitant with the decrease in PPARγ expression, suggesting that Egr-1 recruitment to the PPARγ promoter could mediate the suppressive effect of IL-1 on PPARγ expression.

Moreover, 13-HODE and 15-HETE were shown to mediate the suppressive effect of the anti-inflammatory cytokine IL-4 on inducible nitric oxide synthase expression in macrophages [ 21] and IL-2 production in T lymphocytes [ 22].

These sialic acid residues interact with inhibitory receptors, including DC-specific intercellular adhesion molecule-3-grabbing non-integrin (Anthony et al, 2011; Schwab et al, 2012) and CD22 (Siglec-2) on B cells (Seite et al, 2010), that mediate the suppressive action of IVIG.

Ca2+ is an essential component for efficient elaboration of LPS- and LTA-mediated cytokine response but plays a differential role in mediating the suppressive effects of low pH stress.

Many studies suggest the importance of regulatory cytokines IL-10 and TGF-β in mediating the suppressive activity of Tregs [13].

Initial cell seeding density may be a critical factor in mediating the suppressive effects of CFTR on inflammation as only at a certain density (1×105 cells/well) did we observe the reduction in NF-κB activity.

The EP2 receptor was further implicated in mediating the suppressive effects of PGE2, as siRNA directed against Ptger2, but not scrambled or Ptger4 siRNA, prevented PGE2-induced decreases in Sost.

In conclusion, we report for the first time the existence of a miRNA-regulated mechanism in human islet cells that mediates the suppressive effects of high glucose on insulin biosynthesis.