Sentence examples for mediate the secretion from inspiring English sources
Interestingly, expression of neither Cdc42V12 nor Rac1V12 resulted in increased levels of secreted uPA protein, indicating that although their activities are required to mediate the secretion of uPA in RasV12-transformed PH3MT cells, their activation alone is not sufficient to induce similar increases in expression.
The expression vectors were designed to allow the rapid directional insertion of DNA encoding other immunogenic peptides to mediate the secretion of agglutinating scFv and full-length mAb reagents from transfected mammalian cells.
The K12 T2SS and T4P appear to be non-functional under standard culture conditions, although the T2SS was shown to mediate the secretion of chitinase in the absence of the nucleoid structuring protein H-NS [27] and the T2SS secretin gene was found to be required for surface expression of the DraD invasin [28].
The fibronectin-binding site of TG2 is known to mediate the secretion of TG2.
Nevertheless, ABCB1 has quite low, if any, ability to mediate the secretion of endogenous long-chain phospholipids into bile.
It has been reported that NF- κB could mediate the secretion of proinflammatory cytokines (IL-6 and IL-8) in various types of cancer.
ABC subfamily C member 2 (Abcc2) mediates the secretion of amphiphilic glutathione, glucuronide, and sulfate conjugates into bile.
Mitochondrial DNA also plays a key role in the activation of the NLRP3 inflammasome and mediates the secretion of IL-1β and IL-18 (Yu and Bennett, 2014).
For example, in Alzheimer's disease, it is crucial in mediating the secretion of interleukin-1β following beta-amyloid stimulation [2].
Similarly, mtDNA also plays a key role in the activation of the NLRP3 inflammasome and mediates the secretion of IL-1β and IL-18, which might be associated with the induction of inflammatory disease.
This observation is consistent with our observation that DNCB treatments induced Th2-skewing since Th2 cells are known to play an important role in mediating the secretion of antigen-specific IgG1 from B cells and IL-4 is known to induce isotype switching favoring IgG1 synthesis [24], [25].
