The interaction domain identification results (Table 2) further suggest that in most cases, these N-terminal regions are also likely to mediate the protein-protein interactions.
Therefore, either or both the N- or C-terminus could be involved in NaTrxh secretion and/or mediate the protein-protein interaction of NaTrxh with its target proteins.
DDI-based approaches are often used for predicting both intra-species and inter-species PPIs, with the assumption that domain-domain interactions mediate the protein-protein interactions, because domains are the basic building blocks determining the structure and function of proteins [ 5].
6, 7 Small ubiquitin-like modifiers' conjugation to cellular proteins is a reversible post-translational modification that mediates the protein's function, subcellular land/or expression.
Thus, we propose a putative function for the NR motifs localized at the coiled-coil region and cargo-binding domain of the MS-KIF18A, in mediating the proteins interactions.
These have been shown to be important in mediating the protein-protein interactions between myotubularin subunits [ 3], and might conceivably provide interaction sites for other protein partners.
The two membrane proteins Get1 and Get2 interact with the Get3-TA protein complex and thereby mediate the TA protein release into the ER membrane [ 26, 27].
In contrast, in rodents compelling evidence indicates that SP/NKA mediate the plasma protein extravasation, and CGRP is responsible for most of the vasodilatatory component of the inflammatory response evoked by stimulation of sensory nerve endings in peripheral tissues [2].
