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In order to demonstrate that the linked TP can mediate the nuclear translocation step we took advantage of the described TP-mediated Φ29 minimal amplification system that requires only four proteins, DNA polymerase, TP, single-stranded DNA binding protein and double-stranded DNA binding protein.
Woodward, C. L., Prakobwanakit, S., Mosessian, S. & Chow, S. A. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1.
North Korea has said it will regard international penalties as an act of war, a position Russia has previously endorsed even as it has tried informally to mediate the nuclear dispute.
The nuclear export components CRM1 (chromosome region maintenance 1) and exportin 4 were demonstrated to mediate the nuclear export of Smad proteins [33] [35].
Altogether, these results support the hypothesis that KPNA5 (importin α6) and not KPNA2 (importin α1) nor KPNA4 (importin α3) specifically might mediate the nuclear transport of BRMS1 towards the nucleus.
These results suggest that the Josephin domain can mediate the nuclear export of the fusion proteins, which requires the context of the Josephin domain plus a sequence downstream this catalytic region.
Similar(44)
In human, TP53 is a tumor suppressor and JAB1 can enhance MDM2-mediated TP53 ubiquitination by mediating the nuclear export and cytoplasmic degradation of TP53.
Importin-β is a nuclear transport factor which mediates the nuclear import of various nuclear proteins.
Yi, R., Qin, Y., Macara, I.G. & Cullen, B.R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
HIV-1 Rev protein mediates the nuclear export of viral RNA genomes.
Yi, R. Qin, Y., Macara, I. G. & Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
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