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miR-23b-3p was downregulated in human colon cancer, which regulates FZD7 or MAP3k1 to mediate the multiple steps of metastasis in vivo.
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How CXCR7 mediates the multiple functions has remained a mystery.
We have investigated the potential role of Wnt7b in mediating the multiple functions of Ihh signaling during endochondral bone development.
TrkA specifically mediates the multiple effects of the nerve growth factor (NGF) signaling through receptor autophosphorylation and downstream induction of the mitogen-activated protein kinase (MAPK) and protein kinase B (PKB/AKT) pathways [ 1].
PTH may mediate the induction of multiple myeloma.
According to the previous study [ 5], it was hypothesized that elevated PTH may mediate the induction of multiple myeloma (MM) through the downstream biologic effects of interleukin 6 (IL-6).
Although identified as a trxG component in the context of Hox regulation at active chromatin within regulatory elements in Drosophila[ 28], GAF was subsequently shown to be associated with enhancer-blocking activity as well and GAF-dependent boundaries mediate the activity of multiple homeotic enhancers in Drosophila[ 29, 30].
If there is a creative class, in Richard Florida's phrase, there is also emerging what might be called a fusion class: people positioned to mediate among the multiple societies that claim them.
It has been also demonstrated in model simulations that dual oscillations (i.e. subset of cells fire synchronously during a given gamma cycle) mediate the active maintenance of multiple short-term memories.
It is more likely that multiple endophenotypes mediate the relation between genotype and phenotype, and together are more powerful in predicting the phenotype.
Therefore, we conclude that a proximal function of Parkin recruitment to depolarized mitochondria is to mediate the proteasome-dependent degradation of multiple mitochondrial outer membrane proteins.
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