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The present study indicates that collagen fragments can mediate the migration of bone marrow stromal cells.
In contrast, less is known about how the geometric cues mediate the migration dynamics of cells.
CCL2 signaling has been reported to mediate the migration of MDSCs [27] and arginase 1 is an important pathway for mediating the suppressor function of MDSCs [28].
Inflamed transplanted tissues can themselves produce an 'early' wave of chemokines, including Gro-β/CXCL2, Lix/CXCL5, MCP-1/CCL2, MIP-1α/CCL3 and MIP-1β/CCL4, which can mediate the migration of immune cells to the site of tissue damage or injury [9], [19].
Chemokine receptors mediate the migration and tissue localization of lymphocytes.
For example, Itgα3 associated with Itgβ1 have been shown to mediate the migration of endothelial cells and angiogenesis [ 49].
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Integrin αvβ3 is a molecule which mediates the migration of endothelial cells through the basement membrane during blood vessel formation.
Recent literature indicates that CD177 mediates the migration of neutrophils across endothelial cells via interactions with proteinase 3 (Kuckleburg et al., 2012; Kuckleburg and Newman, 2013) and PECAM-1 (CD31) (Sachs et al., 2007; Bayat et al., 2010), as well as the degranulation and superoxide generation in a Mac-1-dependent manner (Jerke et al., 2011).
We used the same chemical inhibitor approach taken with EpRas to determine what pathway was mediating the migration of PC3 cells.
The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells.
It has been documented that Wnt5a is upregulated during pancreatic carcinogenesis and mediates the migration and invasion of pancreatic cancer cells induced by the transcription factor CUTL1 [ 15].
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