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G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to hormones and neurotransmitters.
Correspondingly, AMPA-subtype ionotropic glutamate receptors, which mediate the majority of excitatory neurotransmission and contribute to seizure generation and spread, have emerged as promising targets for epilepsy therapy.
Earlier studies in rice also suggested that trans effects mediate the majority of the transcriptional differences in hybrid offspring and to a lesser extent, intergenerational epimutations (Chodavarapu et al. 2012).
As mentioned previously, AMPA receptors are the brain's most abundant glutamate receptors and mediate the majority of its excitatory activity.
Protein complexes mediate the majority of cellular processes.
AMPA receptors mediate the majority of mammalian fast excitatory neurotransmission and play important roles in synaptic plasticity.
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Angiotensin II (Ang II) exerts its effects through the binding of two major receptors: the Ang II type-1 receptor (AT1R) which mediates the majority of the pro-atherogenic well-known Ang II actions and type-2 receptor (AT2R) that is considered counteracting the AT1R-mediated effects [ 3].
Specifically, coagulation factor × (FX) binds to the capsid hexon protein and mediates the majority of the Ad5 liver tropism, presumably via heparin sulfate proteoglycan-mediated pathways [38], [39], [40].
There is a high concentration of receptors in the SCN because this is where melatonin mediates the majority of its affects on circadian rhythm.
The ubiquitin proteasome system (UPS) mediates the majority of protein degradation in eukaryotic cells.
The eukaryotic protein kinase (ePK) domain mediates the majority of signalling and coordination of complex events in eukaryotes.
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