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In this regard, it is likely that the different combinations of heteromeric formation of TRPC members of the TRPC family might mediate the main driving forces during the process of the neuronal differentiation of NPCs.
While the topology of this pathway resembles multivesicular endosome formation, genetic studies in yeast revealed that it requires a subset of the same genes that mediate the main, macroautophagic pathway.
SLC1A3/EAAT1 and SLC1A2/EAAT2 are predominantly expressed in glia cells and presumably mediate the main load of glutamate re-uptake while eliciting only small chloride currents [ 18, 20].
Life satisfaction was found to mediate the main effect of prognostic awareness on the DRS. However, there may be an indirect impact of prognostic awareness on the DRS through its relationship with life satisfaction.
Consistent with the previous analysis, the network shows that metabolic pathway members involved in trehalose biosynthesis, in particular Tps2 and Tsl1, are the most downstream transcriptional components of the glucose regulatory system and are therefore predicted to mediate the main transcriptional response to perceived glucose availability.
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The results show that current risk factor score mediates the main relationship between childhood social position and later onset of type 2 diabetes.
To evaluate the possibility of outliers mediating the main effect, a scatterplot of GAF-F by YMRS scores was performed and examined.
TrkA is the high affinity catalytic receptor for the NGF and it mediates the main effects of NGF, which include cell growth, the formation and regeneration of neurites, and avoidance of programmed cell death [ 39].
The membrane is the main cell structure, which mediates the primary interactions between the cell and the environment.
In the presence of covariates, count scores of externalizing and internalizing disorders were investigated as endophenotypes mediating the significant main effects identified in the final models of suicide attempts, mood disorders, and anxiety disorders.
Myrosinases have been extensively studied in plants from the family Brassicaceae because these enzymes mediate the hydrolysis of glucosinolates, the main secondary metabolites found in these plants, leading to a labile aglycone, which rapidly undergoes spontaneous rearrangement to yield a variety of toxic metabolites such as isothiocyanates, thiocyanates, cyanoepithioalkanes and nitriles.
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