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Indeed, a number of diterpenes were identified that bound to recombinant Dopamine receptors of the 2 subtype (D2 receptors) which are present in pituitary lactotropes and which mediate the inhibitory effects of dopamine and dopaminergic drugs on pituitary prolactin release.
A lateral unit, derived from the local signal spread of these channels, was hypothesized to mediate the inhibitory interactions on these centre units [14].
However, since the ANP receptor activates the particulate GC, cGMP is a good candidate to mediate the inhibitory effect of ANP on basal ICa,L.
To rule out that IgM or unspecific effects of serum did not mediate the inhibitory capacity, we purified IgG from both inhibitory and non-inhibitory sera and tested them in inhibition of binding assays at 0.5 mg/ml.
2BP treatment did not significantly affect the mRNA levels of Runx2 or Atf4, suggesting that Runx2 and Atf4 are unlikely to mediate the inhibitory effect of 2BP on osteoblast differentiation.
Sufficient PGE2 to mediate the inhibitory effect was made by either WT POBs or WT BMMs.
Similar(31)
In a threatening context, perceived threat of pain mediated the inhibitory effect of social presence on pain expression, suggesting that the observer acted as a safety signal.
Nogo receptor 1 (NgR1) mediates the inhibitory effects of several myelin-associated inhibitors (MAIs) on axonal regeneration in the central nervous system.
EphA4 mediates the inhibitory effect on Schwann cell migration, and EphA4 knock-down can strongly increase Schwann cell migration and peripheral nerve regeneration.
Our review will help the reader gain a deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcγRIIB and may provide insights to a new therapeutic target for the associated diseases.
The inhibitory effect of adrenaline runs in parallel with an increase in intracellular levels of cAMP which was reversed by the protein kinase A (PKA) inhibitor H-89, suggesting a role for PKA in mediating the inhibitory effect of adrenaline on fMLP-induced superoxide production.
More suggestions(14)
reconcile the inhibitory
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facilitating the inhibitory
mitigating the inhibitory
mediate the complex
mediate the specific
mediate the initial
mediate the electromagnetic
mediate the synaptogenic
mediate the sedative
mediate the bitter
mediate the favorable
mediate the collapsed
mediate the HV-induced
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