Sentence examples for mediate the inflammatory from inspiring English sources

This observation is associated with the prevalent localization of the complex multimeric assembly of CGRP-R in the vascular smooth muscle where they mediate the inflammatory neurogenic vasodilatation.

Inflammatory cytokines mediate the inflammatory response (IL-1, IL-2, IL-6, IL-8, TNFα) and play a crucial role in the pathogenesis of OHSS.

Pivotal role in atherogenesis is played by macrophages, which are early site for lipid accumulation and mediate the inflammatory and immune response in the intima.

The study in our laboratory (Wei et al., 2015) has shown that mtDNA released from necrotic cells induced by cationic carriers can mediate the inflammatory responses via TLR9 signaling, which reveals a novel mechanism about the inflammatory toxicity of cationic carriers and provides a new vision of designing better and safer cationic carriers for drug delivery.

CD4+ cells are polarized toward the Th1 phenotype and thereby mediate the inflammatory process through which tissue damage occurs [28], [33], [34], [35], [50].

To test the hypothesis that CFTR must be localized to cell surface lipid rafts in polarized airway epithelial cells in order to mediate the inflammatory response, we treated CFBE41o- cells that had been stably transduced with wt-CFTR with methyl-β-cyclodextrin (CD).

Incorporating ASCs also mediated the inflammatory response and promoted a more constructive macrophage phenotype.

PGE2 signals through four G-protein-coupled receptors, including the EP2 receptor that has been investigated for its role in mediating the inflammatory and phagocytic responses to Aβ [4].

Realization of the important role played by UA as a signaling molecule mediating the inflammatory effects of hyperuricemia in adipocytes and leukocytes, as well as in signaling to cancer cells (Figure 3) has emphasized the relevance of managing UA therapeutically which could significantly improve treatment strategies for cancer that is associated with hyperuricemic disorders.

Together suggesting CD28, through either CD80 or CD86 is capable of mediating the inflammatory response and lethality of polymicrobial sepsis.

We also evaluated the level of phosphorylated ERK1/2 which results in expression of pro-inflammatory genes mediating the inflammatory responses characteristic of SCI.