Phytochrome- and cryptochrome-mediated light signals mediate the induction of CCA1, LHY, and PRR9 genes [ 8, 16, 17].
α1B adrenoceptors in rat paraventricular nucleus overlap with, but do not mediate, the induction of c-fos expression by osmotic or restraint stress.
Phosphorylation is known to mediate the induction of CRM1-dependent nuclear export of a variety of proteins ranging from transcription factors to protein kinases27,28,29,30.
To test if the p53 3′UTR could mediate the induction of p53 upon treatment with etoposide we tested the response of the 3′UTR reporter in HEK293 cells and found etoposide significantly induced the expression of the reporter (Fig. 6e) without affecting mRNA abundance when compared to a control reporter lacking the p53 3′UTR (Supplementary Fig. 5G).
For instance, the SMAD3/SMAD4 complex was found to mediate the induction of connective tissue growth factor (CTGF) and interleukin (IL-11), which are critical factors for bone metastasis (Deckers et al., 2006; Kang et al., 2005; Kang et al., 2003; Petersen et al., 2010).
In this regard, PACAP/PAC1 signaling is critically required in the hypothalamus to mediate the induction of the hypothalamic-pituitary adrenal axis and likely plays a role in other areas of the CNS that mediate responses to emotional and other types of stress, such as the amygdala, bed nucleus of the stria terminalis, and locus coeruleus (reviewed in [64]).
Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of Phase II detoxifying enzyme genes through antioxidant response elements.
The uPA promoter contains an NF-kappaB binding site that directly mediates the induction of uPA expression by RelA.
In this case, Egr1 mediates the induction of p35 activating Cdk5, which is necessary for neurite-like outgrowth.
Bone marrow cells induce stable mixed chimerism under appropriate conditioning of the host, mediating the induction of transplantation tolerance.
