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They mediate the import of long-chain fatty acids.
A similar system exists in the inner membrane of mitochondria, where the TIM22 and TIM23 complexes mediate the import of different sets of proteins [ 41].
To acquire iron from the host organism, S. aureus synthesizes two major nonhydroxamate siderophores (staphyloferrin A and staphyloferrin B [ 28, 56]), as well as proteins that mediate the import and utilization of iron bound to heme or transferrin [ 57].
Over time it became evident that Mia40 can mediate the import of a much wider subset of IMS proteins, including some with unconventional cysteine motifs that do not contain a CHCH domain and are larger.
Polynucleotide phosphorylase (PNPase) was proposed to mediate the import of H1 and other RNAs into mitochondria, where H1 RNA was hypothesized to function in the processing of specific mitochondrial tRNA precursors as a quasi-additional mtRNase P [95].
IPO13 is known to mediate the import of UBC9, PAX3, PAX6 (and others), as well as the nuclear export and cytoplasmic release of eIF-1A [ 42, 43], a translation initiation factor that reportedly binds to the 3'SL of the DENV4 and West Nile virus genomic RNA [ 44, 45].
Similar(52)
The Tim8 Tim13 complex, located in the mitochondrial intermembrane space, functions in the TIM22 import pathway that mediates the import of the mitochondrial carriers Tim23, Tim22, and Tim17 into the mitochondrial inner membrane.
KPNA2 is an adaptor protein that mediates the import of signaling factors into the nucleus and the export of response molecules to the cytoplasm.
After the discovery of Mia40, the next step was to determine its molecular mechanism in mediating the import of target IMS substrates.
The sequence targets VacA to the TOM complex of the mitochondrial outer membrane (the translocase of the mitochondrial outer membrane) which mediates the import of mitochondrial precursor proteins from the cytosol.
The ABCD1 gene codes for the peroxisomal transporter ATP-binding cassette subfamily D member 1 (ABCD1, formerly ALDP), which mediates the import of very long-chain fatty acid (VLCFA) CoA esters across the peroxisomal membrane.
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