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Envelope fusion glycoproteins located on the outer surface of the viral membranes mediate the fusion of the viral and cellular membranes [32], [33].
We also tested whether OPA1-S1 could mediate the fusion of liposomes.
SNARE proteins are required for vesicle trafficking and they mediate the fusion between the vesicles and their target membranes.
In the trimeric conformation, the hydrophobic fusion peptide is exposed in DII to mediate the fusion with the membranes of the cell.
N-syb, known as Synaptobrevin or VAMP2 in mice and humans, is a SNARE protein that has long been known to mediate the fusion of synaptic vesicles with the presynaptic membrane to allow neurotransmitter release.
Here, VCP may act to recruit E4B ubiquitin ligase activity to aggregates of misfolded proteins [ 10] and/or mediate the fusion of misfolded protein-containing autophagosomes with lysosomes [ 11].
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However, the molecules mediating the fusion events of TFR recycling still remain to be identified.
The envelope protein of DENV is responsible for mediating the fusion process between viral and host membranes.
The fusion protein of enveloped viruses mediates the fusion between the viral and cellular membranes, allowing the penetration of the viral genomes into the host cell.
The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several essential components have been identified.
The availability of structures of SARS coronavirus macromolecules has enabled the elucidation of their important functions, such as mediating the fusion of viral and host cellular membranes, and in replication and transcription.
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