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Several previous studies have suggested that the direct protein-protein interactions between HD and PD mediate the functional antagonisms between the HD containing selector proteins, such as Proboscipedia (PB) and Antenapedia (Ant), and the PD-dependent Ey (Benassayag et al., 2003; Plaza et al., 2001).
We propose that many transcription factors are evenly expressed in many tissues and that several stimuli mediated by tissue-specific signal transduction machineries mediate the functional activation of specific combinations of them at the protein level only in certain tissues and in defined temporal windows.
For example, it is still unknown how changes in the precise connectivity between different subsets of neurons mediate the functional changes that are achieved, which molecular and cellular processes regulate these events and why increased plasticity can take place during sensitive periods.
Moreover, a number of REST and CoREST targets encode factors that repress alternative neuronal fates (e.g., Lhx8 in CHOLN, Bhlhb5 in GABAN, and Tlx1 in GLUTN), suggesting that REST and CoREST mediate the functional properties of specific neuronal subtypes in a myriad of ways.
Which of these molecules mediate the functional interplay of the dynamic F-actin cytoskeleton with the process of CME?
Studies in other cell systems have begun to shed light on the signaling mechanisms that mediate the functional roles of TRPM7.
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Impaired neurocognitive functioning is considered to be mediating the functional adaptation in depression [ 23, 24].
BTLA mediated the functional inhibition of CD8+T cells by its ligand herpes virus entry mediator, BTLA+PD-1+TIM-3+CD8+T cells were most dysfunctional among NY-ESO-1-specific CD8+T cells in melanoma patients.
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the mammalian receptor mediating the functional effects of the universal stress hormone abscisic acid (ABA) in mammals.
We found strong evidence of a well-defined effective connectivity architecture mediating the functional integration between the IPN and the inferior frontal cortices.
In this study, we examine how the sequence architecture of transcription factor binding sites mediates the functional activity of one of these cis-regulatory modules.
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