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There are many genes in the region of the rs646776 locus (Figure S3), and CELSR2, PSRC1 and SORT1 genes have been suggested to mediate the function of this SNP (or functional SNPs in LD [11], [18] [20].
Protein interactions mediate the function of biological systems, where the evolution of interactions is important to understand the functional mechanism in act (Juan et al. 2008; Lovell and Robertson 2010).
The details of these functions are covered in other articles; here we focus on the interactions between DNA and other molecules that mediate the function of the genome.
These studies indicate that SATB1 could mediate the function of MAR elements in directing the expression of β-globin genes.
The transcription factors, CK2 and PC4, which mediate the function of the human DPE, do not mediate DPE-L function, although they do contribute to the overall constitutive transcriptional activity of the class I promoter in vitro [23].
But since the role of Lhx2 is complete by E10.5, it is unlikely that these cross-repressive interactions might mediate the function of Lhx2.
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Recent studies have identified several downstream pathways that mediate the functions of these receptors.
Because these TGALs likely mediate the functions of NH4 and NH5, we hypothesize that bop-like developmental phenotypes [ 50, 51] would appear in the silenced lines.
Nonetheless, these transcripts are predominantly expressed in hypothalamic neurons and may interact with Hcrt neurons to form neuronal networks that mediate the functions of Hcrt neurons.
The core 3 M-protein complex interacts with CUL9, which has been proposed to mediate the functions of the 3 M complex via the ubiquitylation and degradation of survivin [ 76].
To determine the distribution of specific glyco-receptors that might mediate the functions of this glycan-binding protein, Gal-1-binding sites were assessed by flow cytometry of mouse enterocytes using biotinylated rGal-1.
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