Sentence examples for mediate the epigenetic from inspiring English sources

Literature reporting that PCNA and UHRF1 proteins mediate the epigenetic inheritance in mammalian cells by recruiting Dnmt1, we then hypothesized that the defect of Dnmt1 recruitment on DNA could be due to the disruption of interactions existing between Dnmt1, PCNA and UHRF1 [8], [8].

Taking rice as an example, TALEN and CRISPR/Cas9 could precisely knock out genes [ 88, 89], and also mediate the epigenetic status of genes [ 44].

Histone deacetylases were shown to be overexpressed in CLL, and mediate the epigenetic silencing of microRNAs through removal of the activating chromatin modification H3K4me2.

Typically, lncRNAs mediate the epigenetic modulation and silencing of imprinted gene clusters [ 15] or the silencing of gene clusters that are overlapped by a head-to-head natural antisense transcript [ 32].

Moreover, the expression of embryonic flower 2 is repressed, a gene encoding a protein homologous to Drosophila Polycomb genes which mediate the epigenetic control of homeotic gene expression [ 94].

This PRC2 complex mediates the epigenetic control of developmental patterning through chromatin modification.

These observations suggested that ER signalling mediated the epigenetic effects induced by BPA in the oocytes [ 66].

Below, we focus on these characteristics and their potential role in mediating the epigenetic plasticity of hESCs.

The results therefore strongly suggest that G9a and EZH2 play a central role in mediating the epigenetic silencing of COX-2 in IPF.

Hence, in the case of M males, the RA pathway could be mediating the epigenetic changes needed for the correct adaptation to intrauterine environment variations in collaboration with the upregulated NCoR1.

The so-called methyl-CpG-binding proteins (MBDs) are important constituents of the DNA methylation machinery, since they are directly involved in mediating the epigenetic signal (Bird and Wolffe, 1999).