Sentence examples for mediate the downregulation from inspiring English sources

The role of NPY neurons may not be limited to the feeding circuits, per se, since GHRH neurons express NPY Y2 receptors which mediate the downregulation of GHRH mRNA induced by long term fasting in rodents [25], [26].

However, underlying mechanisms that mediate the downregulation of miR-22 in HCC are still elusive.

Endocrine therapy with the antioestrogen tamoxifen can mediate the downregulation of c- myc, culminating in cell cycle arrest [ 44].

However, underlying mechanisms that mediate the downregulation of miR-328 in SP cells have not been elucidated.

which is thought to mediate the downregulation of protein synthesis required for survival during dormancy (Hampshire et al, 2004).

Monocytes of patients will be harvested and tranfected ex vivo with siRNAs that mediate the downregulation of the inducible immunoproteasome subunits LMP2, LMP7 and MECL1.

To determine the molecules mediating the downregulation of EGFR, we performed quantitative proteomic analysis by employing stable isotope labeling with amino acids in cell culture (SILAC) in combination with LC-MS/MS.

Based on studies in SHP-deficient mice, it has been proposed that the induction of SHP mediates the downregulation of SREBP-1c expression in response to bile acids treatment [18], [19], [31].

Western blotting showed that Slug overexpression mediated the downregulation of E-cadherin and the upregulation of N-cadherin, vimentin, and fibronectin (Fig. 1C).

Some of the CMs induce autophagy via several signaling pathways that mediates the downregulation of mammalian target of rapamycin (mTOR) and upregulation of Beclin-1 [ 4, 5, 12].

As GSK3 β is a kinase involved in PGC-1 α degradation, we wonder whether GSK3 β mediates the downregulation of PGC-1 α by Omi.