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The gills are a high energy-demanding multiple-function organ which contains at least pavement cells (equivalent to keratinocytes), neuroepithelial cells, mucous cells, and branchial ionocytes to mediate the diverse functions of air exchange, oxygen sensing, protection, acid-base balance, and ion transport [5].
However, recent evidence indicates that Aβ42 can form a variety of misfolded structures, including multiple monomer conformers, different types of prefibrillar assemblies, and structurally distinct amyloid fibrils, and that such structural polymorphisms may mediate the diverse toxic effects of Aβ42 [10] [13].
Five melanocortin receptors (MCRs) mediate the diverse actions of the melanocortins.
The two estrogen receptors (ERs), ERα and ERβ, mediate the diverse biological functions of estradiol.
Thus, knowledge of the downstream pathways that mediate the diverse functions of Syk are of considerable interest.
Opioid receptors are widely distributed throughout the peripheral nervous system and CNS, and the locations of these receptors mediate the diverse effects of opioid agonists (Le Merrer et al., 2009).
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Gastrointestinal motility is the underlying program that mediates the diverse functions of the intestines, as an organ.
The identification of those target genes is crucial for mediating the diverse biological effects of STAT3 signaling.
The intricate, non-random connectivity of cortical brain regions mediates the diverse and flexible sensory, cognitive and behavioral functions of the mammalian brain.
Based on existing evidence, it is also conceivable that membrane-anchored APP and secreted APP fragments share equal relevance in mediating the diverse physiologic roles of APP.
On the other hand, the class of body regulator that is targeted by 'hot' or 'cold' foods and mediates the diverse 'hot/cold' syndrome must be one that has a wide range of functions or can trigger diverse physiological changes in the body.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com