Sentence examples for mediate the differentiation from inspiring English sources
Given that HSCs are progenitors of platelets, we speculate that the transplanted CD34+ cells may directly differentiate into or mediate the differentiation of platelets which are important for vessel wall maturation and the recruitment of mural cells [61].
Specific signals and cytokines mediate the differentiation of Tregs and Th17 cells [ 41, 42].
To mediate the differentiation of C2C12 cells to osteoblasts, C2C12 cells were first plated at a density of 2 × 10 cells in 24-well plates.
In addition, recent data have demonstrated that fibroblast-like cells mediate the differentiation of macrophages into osteoclast-like cells [ 11, 12].
Furthermore, SYK-induced serine phosphorylation is required for the ability of IK to mediate the differentiation of human B-cell precursors (Uckun et al., 2012).
However, as levels of other differentiation markers were unaffected, it is likely that downregulation of Brk may be an early/intermediate event in differentiation and is not a sufficient signal alone to fully mediate the differentiation process.
G6PI is identical to neuroleukin, a neurotrophic factor for spinal and sensory neurones [ 100, 101], which is associated with terminal sprouting; autocrine motility factor [ 102], which stimulates motility via a receptor-mediated pathway [ 103]; and maturation factor, which mediates the differentiation of human myeloid leukemic HL-60 calls to terminal monocytic cells [ 104].
It mediates the differentiation of B-cells and enhances immunoglobulin secretion [ 12, 13].
These results suggest that c-Fms plays a central role in the pathogenesis of RA by mediating the differentiation and priming of monocyte lineage cells.
It possesses immunoregulatory and immunosuppressive effects in the gut through mediating the differentiation of naive T cells to Th2 cell and inducing Th2-type CD4+ T cells to shift towards a Th1 response [ 16- 19].
We suggest that down-regulation of developmental transcription factors may mediate the aberrant differentiation in ccRCC.
