Sentence examples for mediate the deleterious from inspiring English sources

In other words, it remains unclear whether GLAP could mainly mediate the deleterious effects of Gly-AGEs on HUVECs.

This elevation in systemic NO levels which characterizes cardiomyopathy and PH in human and animal models may reduce myocardial contractility and mediate the deleterious effects of various cytokines on intrinsic myocardial inotropic activity [ 28, 29].

However, since incubation of glyceraldehyde with proteins will generate a large number of structurally distinct AGEs, it remains unclear what type of AGE structures could mediate the deleterious effects of Gly-AGEs on ECs.

Given that much, if not all, of the death has already occurred by this time point, it seems unlikely that a change in system xc− expression is necessary to mediate the deleterious effects of system xc− under aglycemic conditions.

These alterations, except increased portal endotoxin levels, were markedly blunted in fructose-fed TLR-4 mutant TLR-4 mutantr confirmice the LPS-TLR-4 axis may mediate the deleterious metabolic efurtherof exconfirmingucthee intake (33).

In the context of extrinsic aging, AGEs seem to render cells more sensitive to external stimuli, as UVA irradiated fibroblasts and keratinocytes exhibit decreased viability after exposure to AGEs., Oxidative stress has been widely accepted to mediate the deleterious effects of solar radiation in the skin during photoaging.

It is therefore possible that activated Src mediates the deleterious effect of TG2 on cartilage integrity.

However, plants are capable of mediating the deleterious effects of these ROS [ 22] by activating an extensive network of antioxidants.

To date, the molecular mechanism that mediates the deleterious effects of excess iodide in humans is largely unknown.

A growing body of evidence demonstrates that the TLR family, particularly TLR-4, plays the dominant role in mediating the deleterious effects in renal IRI [ 12, 13].

It also discusses areas of intersection between stress and reward pathways, as these are likely important in mediating the deleterious effects of stress on substance abuse and addiction.