Sentence examples for mediate the degradation from inspiring English sources

Together, these data provided evidence that Itch may mediate the degradation of RASSF5A via poly-ubiquitination/proteasome-mediated pathway.

ATPase-mediated acidification in the caveosomes maintains cathepsin-B in activated status to mediate the degradation of consumed cells.

Carotenoid cleavage dioxygenases mediate the degradation of carotenoids to apocarotenoids.

The photoelectrocatalytic (PEC) activity of the composites was evaluated through their ability to mediate the degradation of phenol.

Zhang, Q. et al. Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.

They transcribe short hairpin RNAs (shRNA) that, after being processed into short interfering RNAs (siRNAs), mediate the degradation of the target mRNA.

We confirmed this assertion as Nef and MHC-I complexes were not directed to degradative compartments (Fig. 5a) and MHC-I was not degraded (Fig. 5e), whereas Nef mediated the degradation of CD4 as previously described (Fig. 5e and ref. 40).

These finding suggests that Itch mediates the degradation of RASSF5 by proteasome-mediated pathway in acetylation-dependent manner.

In addition to regulating Runx2 degradation, Smurf1 mediates the degradation of Smad1, a downstream mediator of BMP receptors, and thereby inhibits BMP-induced osteoblast differentiation.

Selective autophagy mediates the degradation of cytotoxic materials, including misfolded protein aggregates, pathogens, and damaged mitochondria50.

One mechanism of thalidomide teratogenicity involves binding to the CUL4 CRBN E3 ubiquitin ligase complex, which then mediates the degradation of transcription factors.