For example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm that is inherited from the egg; in mice, Blimp1 expression in the epiblast mediates the commitment of cells to the germ line.
Cdks are serine/threonine kinases that work in complexes with different types of cyclins to phosphorylate the retinoblastoma family of tumour suppressor proteins (pRB) mediating the commitment of the cells to enter cell cycle in response to external stimuli (reviewed in Ortega et al, 2002).
Besides phenotypic similarities between erythrocytes and thrombocytes found in nonmammalian vertebrates, this includes the common progenitors of these cells (TEPs/MEPs), similarities between EPO and TPO signaling, and shared signaling mechanisms mediating the lineage commitment.
These data support the hypothesis that sensitivity to IFN-γ decreases with increasing osteoclast differentiation and that the mechanism by which RANKL and IFN-γ reciprocally inhibit each other in pre-osteoclasts is mediating the irreversible commitment into the osteoclast or activated macrophage lineages.
As the model indicates, engagement and commitment could mediate the relationship between the disequilibrium of efforts and rewards and employees′ general health [ 26].
Several lines of evidence indicated that miR-705 and miR-3077-5p worked together to mediate the shift of cell lineage commitment of MSCs to adipocytes during osteoporosis.
Structural equation modeling (SEM) results showed commitment and effort mediate the relationships between co-workers' and supervisors' support and advocacy.
Integrating social exchange (SET) and conservation of resources (COR) theories, this research investigates whether employees' personal resource investment in commitment and effort, mediate the relationships between social resources (i.e., co-workers' and supervisors' support) and employee advocacy behaviors.
In the present study, given that several different variables may act as mediators between POS and JP, we consider the possibility that employees' affective commitment may partially mediate the relationship between POS and JP.
These results identified mex3-1 as a cell fate regulator, broadly required for differentiation, and suggest that mex3-1 helps to mediate the balance between ASC self-renewal and commitment.
