Sentence examples for mediate the cleavage from inspiring English sources

In the cytoplasm, the miRNA:miRNA* duplex is separated, and the mature miRNA is incorporated into the RNA-induced silencing complex (RISC) to mediate the cleavage of target mRNAs (Chen 2005).

In strain F, certain mutations were detected in pcaD (β-ketoadipate enol-lactone hydrolase), pcaC (γ-carboxymuconolactone decarboxylase), pcaB (β-carboxy-cis,cis-muconate cycloisomerase), and pcaGH (protocatechuate 3,4-dioxygenase), which mediate the cleavage of the aromatic rings of PCA through the formation of γ-carboxy-muconolactone (Additional file 2: Table S1).

The presence of these additional residues allow us to speculate that RelE2Spn could mediate the cleavage of translating mRNA [16] but also could have an intrinsic RNase activity able to cleave untranslated mRNA, as shown for EcoliYoeB [6].

In particular, caspase-7 was reported to mediate the cleavage of RTN-4B.

As mentioned previously, caspases mediate the cleavage of Livin into a truncated form, tLivin, that is paradoxically a proapoptotic protein.

To test whether the identified miRNAs could mediate the cleavage of the predicted target mRNAs, a 5' RACE experiment was performed.

After the Nt.BbvCI mediated the cleavage of MB, the released partial substrate strand could hybridize with another MB probe again and be re-used for the second cycle of cleavage.

In this study, we show that PS/γ-secretase mediates the cleavage of neurexins at synapses.

By incorporated into a protein complex, the siRNA duplex becomes a component of the RISC and mediates the cleavage of target RNAs [24], [27].

Western blot analysis of MDCK cells expressing individual subunits revealed that meprinβ but not meprinα mediated the cleavage of E-cadherin (Figure 1B).

The presence of HvPHO2-associated sRNAs in P-deficient barley could substitute for miR399 in mediating the cleavage of HvPHO2.