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All clinically approved antibodies are of the IgG isotype and mediate the clearance of target cells via binding to Fcγ receptors and complement (C1q).
For influenza virus infection, antibodies are thought to mediate protection while T cells mediate the clearance of the virus [1].
We hypothesized that B. pertussis-induced antibodies could recognize B. bronchiseptica antigens and mediate the clearance of this pathogen.
LRP-1 was indeed reported to mediate the clearance of various matrix metalloproteinases such as MMP-2, MMP-9 and MMP-13 [8], [9], [9] and to regulate the plasmin activation cascade through endocytosis of tissue-type (tPA) or urokinase-type (uPA) plasminogen activators [10], [11].
These receptors mediate the clearance of endogenous cells directly or indirectly via PS-binding proteins.
Importantly, both reactive astrocytes and activated microglia express scavenger receptors that mediate the clearance of extracellularly-deposited fibrillar Aβ [ 1].
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Finally, as emerging evidence unravels the role of autophagy in mediating the clearance of RNA-protein aggregates (Frankel et al., 2017), the observed dependence on autophagy for degradation of misassembled viral complexes shown in this study could potentially serve as a model system for understanding how misassembled RNA-protein complexes are generally disposed of by cells.
We hypothesized that IgM mediates the clearance of small particles by macrophages.
By interacting with its receptors, apoE mediates the clearance of different lipoproteins from the circulation [39].
The data illustrates that IgM opsonization preferentially mediates the clearance of the smaller particles, whereas IgG opsonization mediates the clearance of particles of various sizes, showing a positive trend for enhancing the clearance of larger particles.
This would suggest that the cellular immune responses might be involved in mediating the clearance of LVS and eventual recovery.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com