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Activation of the neurons in the trigeminal ganglion leads on the other hand to an activation of neurons in the trigeminocervical complex that project to the central nervous system (CNS) and mediate the central aspects of pain [1, 9].
Considering the small size of these hydrophobic sequences, it is unlikely that it exerts a catalytic function, but interactions with conserved transmembrane proteins could mediate the central TMD function.
α2-ARs are G-protein coupled receptors that mediate the central and peripheral actions of the primary sympathetic neurotransmitter, NE and the adrenal hormone epinephrine through the intracellular suppression of cAMP [11].
The pathways that mediate the central circadian control over bladder function are not clear.
Note that the annotation matched two different maize transcripts to the same Arabidopsis gene (PFK3), which explains the different phase values shown in Table 2. PFK enzymes mediate the central regulatory step of glycolysis.
Thus, the identification of UBE2T as the 18th FA gene is consistent with current models of the FA pathway and confirms again the intimate connection between the 'early' proteins in the FA pathway, including FANCA/B/C/E/F/G/L/M and UBE2T (T), which together mediate the central step activation step, monoubiquitination of FANCD2 and FANCI.
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Noradrenergic pathways are involved in mediating the central and peripheral effects of physiological arousal.
Wild type mice were injected unilaterally with a recombinant adenovirus-associated virus producing a localized increase in NPY expression (rAAV-NPY+) in the hypothalamus, targeting the arcuate nucleus (Arc) (Figure 4a), the brain region critical in mediating the central effects of Y receptor signaling on both energy balance and bone mass [6], [8].
These data identified novel regulators, endogenous receptors, in determining local clock activity, in addition to mediating the central control.
Their secretion are also governed by the same regulatory pathways mediated by the central, peripheral, and enteric nervous system and by gastrointestinal hormones and mediators released during the passage of ingested food components.
Our experiments, for the first time, revealed that the anti-morphine effect of pDBIs and bDBI-16 is mediated by the peripheral type of BDZ receptor, while the morphine-enhancing effect of bDBI-19 is mediated by the central type of BDZ receptor (Fig. 2E and 2F).
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communicate the central
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com