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As the p53 and p16/Rb pathways are important mediators of cell senescence [ 18, 19], we wondered whether they might mediate the cell proliferation arrest and upregulation of SASP-component expression observed in response to pro-senescence kinases.
Cyclin A (CCNA2) was identified as a direct target gene of REV-ERB suggesting that suppression of expression of this cyclin by SR9011 may mediate the cell cycle arrest.
The results indicate that the mir-shRNAEGFP-SV40-1 is able to mediate the cell subtype-specific knockdown of a chromosomally integrated gene in a genetically heritable manner.
It is possible that a LexA target interacts with FtsZ in C. crescentus, to mediate the cell division arrest observed upon starvation [10].
These results implied that integrins might mediate the cell adhesion to AGM.
ROS has been shown, via Erk1/2 pathway, to mediate the cell proliferative effects [ 9, 18].
Similar(42)
Moreover, flow cytometric assay revealed that quercetin and QS could mediate the cell-cycle arrest principally in the S phase after 24 h of treatment with the two tumor cells.
We have sought to identify pathways that mediate the cell-autonomous growth suppressor activity of the Drosophila endocytic gene ept, which encodes a homolog of mammalian Tumor Susceptibility Gene-101.
The transmembrane glycoprotein establishes homophilic interactions with adjacent E-cadherin molecules forming the epithelial junctional complexes, which mediate the cell-cell adhesion in the epithelial tissues [ 11].
CD44s and CD44v have been shown to mediate the cell-extracellular matrix interaction in various biological processes such as lymphocyte homing [ 12], hematopoiesis [ 13], embryogenesis [ 14], and wound-healing [ 15].
Plant cells are able to sense and transduce signals through cell surface receptors which mediate the cell-to-cell communication by binding to the extracellular ligands and possessing protein kinase catalytic activities [ 1].
More suggestions(15)
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