Sentence examples for mediate the apoptotic from inspiring English sources

Some of the caspase family proteins such as caspase-7, caspase-8, and caspase-9 are widely accepted to mediate the apoptotic pathway.

Human melanomas express functional P2X7 receptors that mediate the apoptotic functions of ATP, whereas P2Y1 and P2Y2 receptor agonists caused a decrease and increase in cell numbers, respectively.

Thus, in our study TRAIL has emerged as a likely candidate to mediate the apoptotic effect of RA/poly(I C) combination in breast cancer cells.

2 6 8 10 Of additional relevance to the present study is the observation that netrin-1 receptors can mediate the apoptotic response of the intestinal epithelium.

To determine whether nuclear receptors mediate the apoptotic effect of fenretinide in HCC cells, the basal mRNA levels of twelve nuclear receptors were assessed by real-time PCR.

Several downstream targets, such as Bim, Bad, p53 and C-Jun, have been well documented to mediate the apoptotic effect of JNK activation.

Also, it induced the morphological changes and mediated the apoptotic cell death of HCT-116 cells with perturbance in mitochondrial membrane potential (MMP) and PARP cleavage.

While Stat3 contributes to oncogenesis, in part, through inhibition of apoptosis, Stat1 is anti-oncogenic; it mediates the apoptotic effects of interferons and contributes to tumor immunity [14], [34].

Because we found that 1 µM CP-55,940 increases ERK1/2 signaling in CB1-low DBT cells without affecting the AKT, JNK, p38 and GSKβ signaling pathways, and one study suggested that ERK1/2 mediates the apoptotic properties of cannabinoids on astrocytomas [8], we then tested if inhibiting ERK signaling would affect the CB1-mediated and the cannabinoid receptor-independent killing of DBT cells.

However, ATF3 has also been shown to promote cell death by mediating the apoptotic effects of p38 MAPK [31], and its expression preceded the death of spinal motor neurons and correlated with phosphorylation of c-Jun in a mouse model of familial amyotrophic laterals sclerosis [108].

As a consequence, ceramide is formed which mediates the apoptotic signal.