Sentence examples for mediate the aggressive from inspiring English sources

The molecular mechanisms that mediate the aggressive phenotype in gliomas, however, are incompletely understood [ 44- 46].

Therefore it is hypothesized that overexpression of TGF-β1 and activated IL-6 signalling could mediate the aggressive tumour growth and treatment resistance in oral cancer.

VEGF may in part mediate the aggressive breast cancer (BC) phenotype associated with HER2 overexpression [ 18, 19], and constitutively active HER2 has been shown to increase VEGF protein synthesis levels in human BC cells [ 20].

TGF-β1 has been reported to up-regulate IL-6 expression, and the TGF-β1/IL6 axis could mediate the aggressive tumour behaviour and treatment resistance observed in lung cancer [ 11].

Current IBC-specific treatments are very limited and development of new therapeutics is needed, specifically therapies against pathways that mediate the aggressive IBC phenotype.

Our results demonstrate that EPCR is overexpressed by RASFs and mediates the aggressive behavior of RASFs.

To further investigate the molecular mechanism mediating the aggressive effect of TBLR1, the levels of epithelial mesenchymal transition (EMT) markers were examined.

Although our findings suggest that DEC1 may contribute to mediating the aggressive phenotype of hypoxic tumours, we did not demonstrate a significant association between DEC1-positive tumours and relapse-free or overall survival that has been reported for hypoxic node-negative and node-positive breast tumours (Schindl et al, 2002; Bos et al, 2003).

These results suggest that cyclin D1 and p21 may cooperate with each other to mediate the tumor-promoting effects of TGFβ in aggressive breast cancer cells.

In rats it is possible that aggressive interactions among cagemates could mediate the effects of stress on behavior.

Is the overexpression of CYGB necessary to mediate the hypoxia response, to mediate VEGF expression (Fordel et al, 2004a), to subtend a survival advantage in more aggressive tumours?