Sentence examples for mediate terminal differentiation from inspiring English sources

CONCLUSIONS: These results indicate that Epo can deliver differentiative signals along a non-erythroid lineage, providing evidence for interchangeable cytokine receptor signals that mediate terminal differentiation of committed myeloid cells.

Specifically, ZEB1 promotes the expression of established key adipogenic regulators such as PPARγ and C/EBPα, and balances against pathways that repress and in favor of those that mediate terminal differentiation.

To study lineage-specific effects of cytokines during terminal hematopoietic differentiation, we examined the ability of erythropoietin (Epo) to mediate terminal granulocytic differentiation and induction of myeloid gene expression in committed myeloid cells, engineered to ectopically express Epo receptor (EpoR).

RESULTS: Studies of EpoR function in myeloid EPRO cells revealed that Epo/EpoR interaction can mediate terminal granulocytic differentiation of committed myeloid cells.

Conversely, incubation with NOS inhibitors reversed the increase in alkaline phosphatase activity, whereas cGMP inhibitors reversed the increases in alkaline phosphatase activity and collagen expression, demonstrating that NO helps to mediate the terminal differentiation of chondrocytes.

Lateral aggregation of P1a molecules in HDs also appears to protect P1a from degradation via calpains, a family of calcium-dependent proteases that could be involved in HD destruction to mediate migration and terminal differentiation (Kostan et al. 2009; Walko et al. 2011).

It thus appears that IFN-γ anti-osteoclast activity is mediated by inducing terminal differentiation away from the osteoclast lineage, while IL-4 directly interferes with RANKL signaling during osteoclastogenesis.

This is consistent with the fact that PPARβ/δ is required to mediate the induction of terminal differentiation in epithelial cells [ 5- 10].

At implantation, DNMT3b catalyses de novo methylation to repress the germline expression programme and mediate the transition to terminal differentiation programmes (Borgel et al., 2010).

Therefore, it seems unlikely that pRB directly regulates GrB promoter in breast cancers; it is more likely that the overexpression of pRB mediates senescent arrest and/or terminal differentiation (Hinds and Weinberg, 1994; Xu et al, 1997), resulting in endo-GrB expression that occurs prior to the onset of the postsenescent apoptosis of the tumour cells.

Our results showing defects in cell migration in CEDNIK fibroblasts highlight the importance of membrane fusion mediated by SNAP29 for normal terminal differentiation of the skin.