Sentence examples for mediate synaptic plasticity from inspiring English sources
In January 2016, he will begin his own laboratory at Johns Hopkins University, where he will study the membrane and protein dynamics that mediate synaptic plasticity.
Evidence from several elegant studies have suggested that opposing cellular actions of mBDNF and proBDNF mediate synaptic plasticity [55].
The molecular mechanisms that mediate synaptic plasticity are beginning to be elucidated; many of the key components involved are synaptic scaffolding molecules of the membrane-associated guanylate kinase (MAGUK) family such as PSD-95 and PSD-93 [2], [2].
A Neurexin/Neuroligin/Shank signaling pathway (Bourgeron, 2009) could not only be important to stabilize synaptic contacts, but also to mediate synaptic plasticity and maturation.
Therefore, through its modulatory effect on ATF4, DISC1 might be involved in the regulation of the transcriptional events that mediate synaptic plasticity.
Interestingly, LTP can be modulated by other neurotransmitters such as dopamine and acetylcholine [ 37, 56] and the muscarinic M1 subtype of cholinergic receptors are known to mediate synaptic plasticity by inhibiting small-conductance Ca2+-activated potassium (SK) channels at hippocampal synapses [ 8, 13, 25].
Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine.
Leu-enkephalin, an endogenous opioid peptide found in the hippocampal mossy fiber pathway, plays a critical role in mediating synaptic plasticity at the mossy fiber-CA3 pyramidal cell synapse.
Among its targets, the Ca2+/CaM-dependent protein kinases I and IV (CaMKs) are capable of transducing intraneuronal signals, and these kinases are implicated in neuronal gene regulation that mediates synaptic plasticity in mammals.
Neuropeptide mediated synaptic plasticity is known to involve regulation of gene expression and chromatin structure [38].
In the present study, we have identified IRS2 as a novel component of the signaling apparatus which mediates synaptic plasticity in the hippocampus.
