Sentence examples for mediate synaptic dysfunction from inspiring English sources
For example, PrPC has been shown to bind Amyloid-β oligomers and mediate synaptic dysfunction in hippocampal slice cultures, suggesting a potential role for PrPC in Alzheimer's disease [69].
Substantial evidence indicates that disrupted neuronal calcium homeostasis is an early event in AD that could mediate synaptic dysfunction and neuronal toxicity.
Thereby, mistargeting of hyperphosphorylated tau to intact spines mediates synaptic dysfunction independently of neurodegeneration [ 5].
It was reported recently that tau localization to dendritic spines mediates synaptic dysfunction in FTDP-17 and AD mouse models [ 5, 6].
Substantial evidence indicates that disrupted neuronal Ca2+ homeostasis in these brain areas is likely an early event in AD pathogenesis that mediates synaptic dysfunction and neuronal toxicity (Small, 2009; Li et al., 2011).
Furthermore, these results strongly suggest that Aβ perforations are involved in synaptic dysfunction mediated by Aβ oligomers [17].
Of note, electrophysiological changes and structural atrophy of dendritic spines have been shown to precede significant deposition of neurofibrillary pathology and neuronal loss in rTg4510 mice (52, 53), which suggests that synaptic dysfunction mediated by pathological forms of tau is the basis for the observed behavioral deficits, rather than neuronal loss.
Our results suggest that synaptic dysfunction may mediate a large fraction of strong, individually rare genetic influences on schizophrenia risk.
In this study, we sought to determine whether oxidative stress in the brain of Cln1 −/− mice 22, 23 mediated serpina1 expression and inhibiting neurotrypsin activity and suppressed neurotrypsin‐mediated agrin‐22 production in the nerve terminals leading to synaptic dysfunction.
Several studies showed spine loss or synaptic dysfunction in these models before the appearance of plaques, which was generally interpreted as effects being mediated by soluble amyloid beta [ 29, 32].
Synaptic dysfunction in depression: potential therapeutic targets.
