It is mediated by synaptic adhesion molecules, and is among the earliest and most indispensable of molecular events occurring during synaptogenesis.
This phenotype is consistent with the role of App family members in mediating trans-synaptic adhesion functions (Wang et al., 2009) through homo- and hetero-oligomeric interactions (Soba et al., 2005).
An important mechanism that mediates this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synaptic adhesion molecule neuroligin-3 (NLGN3), which promotes glioma proliferation through the PI3K mTOR PI3K mTOR
Polymorphic adhesion molecules neurexin and neuroligin (NL) mediate asymmetric trans-synaptic adhesion, which is crucial for synapse development and function.
Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation.
Both methods were also used to track single molecules of neurexin, a synaptic adhesion protein, to measure its lateral diffusion in the presence of neuroligin, its trans-synaptic adhesion partner.
Fogel, A. I., Li, Y., Giza, J., Wang, Q., Lam, T. T., Modis, Y., and Biederer, T. (2010) N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion.
Ionotropic glutamate receptors (iGluRs) are tetrameric cation channels that mediate synaptic transmission and plasticity.
α-Neurexins are essential synaptic adhesion molecules implicated in autism spectrum disorder and schizophrenia.
CAMSAPs mediate connections between microtubule minus ends and adhesion proteins at epithelial adherens junctions (Meng et al., 2008), and the synaptic-localized CAMSAPs we observed may play a similar bridging role at synaptic adhesion sites.
