Sentence examples for mediate subtle from inspiring English sources

Full kinetic analysis and multiple X-ray crystal structures of our designs indicate that electrostatic interactions in the distal "switching loop" region and local packing in the hydrophobic core mediate subtle but significant conformational changes that modulate USP7cd activation.

Alternatively, these nAChRs may mediate subtle aspects of motor neuron activity.

Once again, the A-to-G substitution at position 3 in the Y box appears to strengthen DEK binding to the DQA1 Y box in comparison with the DRA Y box; allelic variation in the nucleotide at position 7 in the Y-box sequence (as in DQA1*0501 and in the DR4-associated DRB Y-box sequence) may also mediate subtle differences in DEK binding to otherwise identical sites.

An alternative strategy could be the introduction of double strand break in an intronic sequence to incorporate homologous recombination mediated subtle changes in the adjacent exon.

It cannot be concluded from the present results whether different patterns of connectivity between patients and control subjects represent a general mechanism for mediating subtle attentional biases in rMDD or whether the findings are specific to face emotion-processing.

Differences among villages, possibly mediated by subtle differences in wealth and dietary habits within this generally homogeneous environment, was significant for intakes of vitamin B-12 (P = 0.0023) and betaine (P = 0.0024) and for plasma concentrations of choline (P value= 0.0039), folate (P = 0.0131), methionine (P = 0.0022) and the SAM/SAH ratio (P = 0.0038).

One final caveat in this study is that chorionicity data were not available on these twins, a potential limitation given that whether or not MZ twins share a placenta may influence epigenomic and transcriptional differences mediated by subtle differences in the prenatal environment [ 58].

Just as the Moors sought to create oases mediated by rich and subtle architecture in north Africa and southern Spain, so Barragan aimed to re-create echoes of the Garden of Eden in many of his projects.

As mediated by Raine, Eliot's subtle remark is used - coarsely - to suggest that a preoccupation with ideas is a symptom of artistic coarseness.

Since cooking over a live fire gives food a distinctive element of smoky, charred taste, it further mediates against any attempt to introduce subtle, blended flavors.

However, this led to only a subtle reduction in FAC-mediated increase in lysosome abundance, suggesting that Hsp70 does not have a major role in mediating FAC-induced changes in lysosome abundance in T80 cells.