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While the F-BAR domain binds to membranes with a particular curvature (Heath and Insall 2008), the unstructured central region contains a high-affinity membrane-binding activity that is sufficient to mediate strong membrane association.
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From 2D crystals of bacteriorhodopsin (Grigorieff et al, 1995) and aquaporin (Hite et al, 2010), it is known that lipids can mediate strong interactions between membrane proteins.
Pyramidal cells also activate inhibitory interneurons that mediate strong, local feedback inhibition that scales with excitation.
All positive cells showed strong membrane staining.
DME and MBD4 could mediate strong bulk genome DNA demethylation.
Strikingly, wild-type mCherry-p62 mediated strong bending of the GUV membrane around the beads.
In GPCRs, as well as membrane channels and transporters, amino acid residues with small side-chains (Gly, Ala, Ser, Cys) allow tight helix packing by mediating strong van der Waals interactions between helices.
Matsubu, J. C. et al. Adsorbate-mediated strong metal-support interactions in oxide-supported Rh catalysts.
Invadopodia are protrusive, F-actin-driven membrane structures that are thought to mediate basement membrane transmigration during development and tumor dissemination.
The absence of COOH-tail sequences may have resulted in a receptor that lacks sequences necessary for mediating rapid desensitization and internalization as well as strong plasma membrane expression (PME) [8].
In addition, OPA1-S1 isufficientntoto mediate membrane tubulation.
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