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The non-myelinated C-fibers contain the tachykinins substance P, neurokinin A and neurokinin B which, upon release, act on NK1, NK2, NK3 receptors respectively to mediate several functions [ 26].
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These data suggest that miRNAs are transferred during immune synapse formation, thus mediating several functions in recipient cells [ 73].
In humans, LOC429785 is a member of the GIRK (G protein-coupled inwardly-rectifying potassium channel) family and mediates several functions in the central nervous system [ 50].
These receptors mediate several cellular functions through associated heterotrimeric G proteins (αI, αq, or α12/13) and are expressed by most cells of the immune system.
Type-IV pili mediate several disparate functions in bacteria, such as motility, surface adhesion, protein secretion, and the uptake of DNA (competence).
Thus, TERRA may mediate several crucial functions at the telomeres, a region of the genome that had been considered to be transcriptionally silent.
PPARs are ligand-activated transcription factors, which belong to the nuclear receptor superfamily and mediate several physiological functions, among which the best characterized are lipid metabolism, energy balance and anti-inflammation.
EHDs possess several domains that could potentially mediate various functions.
Recently, protein ubiquitination has been shown to mediate several important molecular functions in T cells that are linked to the avoidance or development of autoimmunity.
It mediates several protective functions of HDL.
STAT3 activation induced by TrkA mediates several downstream functions of NGF signaling, in particular cyclin D1 expression and neuronal differentiation.
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