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Pentatricopeptide repeat (PPR) proteins are a large family of modular RNA-binding proteins which mediate several aspects of gene expression primarily in organelles but also in the nucleus.
ER stress and UPR signaling have been shown to mediate several aspects of the pathogenesis and natural history of atherosclerosis and vascular inflammation [1] [5].
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O-GlcNAc, in concert with ubiquitin, mediates several aspects of diabetic cardiomyopathy [ 53, 65– 65].
O-GlcNAc, in concert with ubiquitin, mediates several aspects of diabetic cardiomyopathy [ 49– 53].
Tachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics.
SAPKs mediate signal transduction to stress and control several aspects of cell physiology from transcription to cell-cycle regulation (de Nadal et al, 2011).
Macrophages potentially contribute to several aspects of the pathologic process mediated by maternal autoantibodies.
Several aspects of the obesity phenotype appear to mediate its negative effect on bone health.
Finally, we showed that GM-CSF may regulate the homing molecules CCR2 and CCR6 on human monocytes [14], which are involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of innate immune cells to the sites of epithelial inflammation.
The present study, although compromised by the small sample size, was able to illustrate several aspects of immunological responses to the endotoxic assault mediated by μG.
But several aspects seemed clear to experts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com