These epigenetic features have allowed the demarcation of boundaries that redefine the minimal Runx2-P1 promotor to include a 336-bp sequence that mediates responsiveness to osteoblast differentiation.
We found that silencing PPARγ expression in THP-1 cells impaired the induction of LXRα and ABCA1 gene expression normally observed with ghrelin (Fig. 1D), in line with an essential role of PPARγ in mediating responsiveness to ghrelin in macrophages.
For instance, regions within exons 11, 12a, and 12b affect transcriptional activator activity of human Meis1 proteins by mediating responsiveness to PKA and TSA (Huang et al. 2005; Shim et al. 2007), and inclusion of exon 12a lowers transcriptional activation in frogs and mammals (Yang et al. 2000; Maeda et al. 2001; Huang et al. 2005); (fig. 3).
Further, the N50 region of AR regulates the characteristics of inclusions formed and mediates its responsiveness to the anti-aggregation effects of Y-27632 and profilin.
Studies with IL-4 and IL-13 reporter mice have revealed the compartmentalisation of adaptive and innate cell populations mediating immune responsiveness to N. brasiliensis.
The CRHRs (CRHR1 and CRHR2) and the melanocortin receptors (MC1R MC5R) mediate the axis responsiveness to integrated signals from diurnal rhythms, cortisol negative feedback via the glucocorticoid receptor, and superimposed stressors.
Using Berkel et al.'s (2011) integrated model of intervention implementation, we examined whether the association between teachers' perception of intervention quality and their improvement in instructional interactions was mediated by their responsiveness to the intervention.
Supporting this model, we found that the association between individual differences in romantic attachment avoidance and MFR was fully mediated by caregiving responsiveness to partner.
Hence, as expected, subsequent rounds of ChIP resulted in an enrichment of SynCREs within the pool of immunopecipitated SynEs mediating expression and/or responsiveness to Pep25.
