Sentence examples for mediate removal of from inspiring English sources

Seenundun and coworkers [ 41] showed that the histone demethylase UTX is targeted to muscle-specific genes by the transcriptional activator Six4 to mediate removal of the repressive H3K27me3 mark during myogenesis.

In the second step, integrative recombinant oligonucleotides, harboring homologous sequences flanking the CORE cassette are introduced, which mediate removal of the CORE cassette while simultaneously inserting the mutation or deletion (Storici et al., 2001).

In conclusion, we have demonstrated that the histone demethylase UTX is targeted to muscle-specific genes by the transcriptional activator Six4 to mediate removal of the repressive H3K27me3 mark during myogenesis.

Pagano and colleagues find that Plk1 and the E3 ubiquitin ligase SCFβTrCP mediate degradation of the centrosome cohesion protein Cep68 and show this mediates removal of Cep215 from the PCM and subsequent centriole separation in late mitosis.

We engineered adeno-associated viruses (AAVs) that express GFP, dsRedExpress, or channelrhodopsin (ChR2) upon Cre/loxP recombination-mediated removal of a transcription-translation STOP cassette.

GFP becomes expressed after Cre-mediated removal of the Id1 transgene ('Id1 reverted').

LoxP site-mediated removal of selection markers from the previously generated knockins prevented exon skipping but left a 45 bp Stop-loxP scar within the targeted exon.

In immune complex diseases, C3 is important in both dissociating larger complexes into smaller units and mediating removal of complexes through the clearance pathway involving erythrocyte or platelet immune adherence receptors [ 102].

Where as the demethylase-dependent function mediates removal of H3K27me3 repressive marks on genes involved in reprogramming such as Ink4/Arf, the demethylase-independent pathway involves PHF20 for ubiquitination, thereby leading to degradation [ 200].

Three distinct ERAD pathways can be defined on the basis of the different ubiquitin ligase complexes involved in substrate elimination: The ERAD-L pathway mediates removal of soluble (luminal) ER substrates whilst depending on the presence of either misfolded transmembrane or cytosolic domains, membrane-anchored substrates are removed by either the ERAD-M or ERAD-C pathway [ 26].

Autophagy, which is a cellular housekeeping system that mediates removal of damaged large organelles and protein aggregates, is an important factor in maintaining muscle fiber integrity [ 36], and deficient autophagy may have a crucial role in the development of ICUAW [ 35].