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Although a handful studies have proposed that antisense transcription could be important in stress related condition [ 8, 36, 37], it remains unclear as to how they mediate regulation with changing conditions and also how conserved is antisense mediated regulation across species.
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The IMPI-peptide encoded by the N-terminal part contributes to innate immune responses by inhibiting microbial metalloproteases, whereas the IMPI-peptide encoded by the C-terminal part of the gene has been implicated to mediate regulation of endogenous matrix metalloproteinases with pleiotropic functions in immunity and development [ 58].
Non-protein coding intronic transcripts have been shown to be enriched in genes related to transcription regulation and interact with promoters to mediate regulation [19], [20].
Batsch flowers mediate regulation of gastrointestinal motility.
In light of important functions of these differentially expressed miRNAs in regulating radish root development, a hypothetical model of miRNAs mediated regulation associated with taproot thickening in radish was put forward.
NR2E1 has previously been shown to mediate gene regulation with co-interacting partners; forming regulatory complexes that lead to either direct-target-gene repression or activation [ 14, 21, 25, 26].
We finally note that on/off and off/on transitions in Myc expression (either as achieved here with Tet-mediated regulation or in other instances with serum deprivation/stimulation) are adequate to study dynamic chromatin regulation by Myc, but will most likely miss its effects in epigenetic reprogramming.
Our results suggest that Kr-h1 is associated with juvenile hormone mediated regulation of reproduction in bumble bees.
In both bee species however, the expression of Kr-h1 in the brain is inhibited by the queen and associated with juvenile hormone mediated regulation of social organization.
PPI sub-networks containing the hub genes involved in T2D-associated signaling pathways revealed that the oxidative stress mediated regulation cascade, is the link, associated with the mechanism of pathogenesis of type 2 diabetes, hypertension and other inflammatory diseases such as obesity.
In breast cancer cells, ERα can mediate genomic transcription regulation with nuclear initiated steroid signalling and non-genomic activation of various protein kinase cascades [ 11].
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