2) The fact that IIPs including membrane proteins are all soluble in unsalted water, but get aggregated upon being exposed to ions, logically suggests that ions existing in the background play a central role in mediating protein aggregation, thus acting as 'dark mediators'.
Mutagenesis studies suggest that Phe residues in this region are critical in mediating protein aggregation.
These results together constitute a fact that logically suggests that despite existing in the background, salt ions play at least an equal important role in mediating protein aggregation.
We then systematically assess the role of the histidine residues in Aβ and how they mediate distinct metal-mediated, oxidative and protein aggregation stresses.
This oligomerisation model does not take into account protein aggregation mediated by the predicted β-strand at the SAS-5 C-terminus.
Previous studies have shown that electrostatic interactions play a crucial role in mediating the process of protein aggregation (Chi, et al., 2003; Yan, et al., 2006).
Generally, HSPs prevent inappropriate protein aggregation and mediate transport of immature proteins to the target organelles for final packaging, degradation or repair.
Of the six signaling pathways unique to P. falciparum infection, "Huntington's Disease Signaling" is the lead pathway that is activated in response to protein aggregation and mediated by chaperones (Figure 5D and Table 4).
BAG3 was recently shown to be involved in cancer-signaling networks, to mediate a selective macroautophagy pathway upon protein aggregation and to attenuate proteotoxicity in cancer cells.
Taken together, these studies imply that this region is likely to mediate protein interactions that play an important role in determining aggregation properties of the Htt peptide.
