Sentence examples for mediate protective immunity from inspiring English sources

Currently there is much interest in its use for nucleic acid mediated immunizations; studies in the 1990s revealed that DNA vaccination could mediate protective immunity, as plasmid DNA incorporated into cells results in an antigen-specific antibody responses (see [ 8- 10] for reviews).

These cytokines form a complex network of molecular and cellular interactions that mediate protective immunity to worm infection, but also induce inappropriate inflammatory responses to allergic challenge.

However, phosphoantigen- activated γδ T cells display a restricted TCR diversity and only a subset of phosphoantigen-responsive γδ T cells mediate protective immunity against tuberculosis [11].

Ad-MSP-142 induces a strong antibody response after two weeks to the 19 kD fragment of MSP-1 (MSP-119), which is thought to mediate protective immunity [36], [37].

Studies have demonstrated that epitope-specific T cell responses elicited by immunization with DNA or peptide, and adoptive transfer of epitope-specific T cell clones, could mediate protective immunity, in some cases with single CTL epitopes, against various pathogens in murine experimental models [32] [42].

Animal studies have shown that ORF2 recombinant proteins elicit neutralising antibodies and mediate protective immunity in vaccinated primates.

To test the relative efficacy of CD4 and CD8T cells in mediating protective immunity to Mycobacterium tuberculosis (Mtb), we compared three immunization regimes designed to induce preferentially each subset.

Typically, helminths induce strongly polarised Th2 responses, which are often effective in mediating protective immunity against those parasites living at mucosal surfaces, but less so in protecting against tissue-dwelling parasites.

Sustaining this balance allows for adequate CD8+ lymphocyte-mediated protective immunity while avoiding the overaccumulation of activated T cells that can predispose to autoimmunity.

Although Th2-associated responses and high levels of IgE correlate with protection in gastrointestinal helminth infections [ 33], our data suggest that IgE may have a limited role in mediating protective immunity against T. crassiceps.

Nonetheless, these studies clearly demonstrate the advantage of using a pathogenic fungus engineered to secrete host cytokines in order to achieve a biological "print out" of those factors that mediate protective host immunity.