Sentence examples for mediate platelet function from inspiring English sources

10 Endothelial cells regulate thrombosis through the release of paracrine factors that mediate platelet function.

Although Vav1 is phosphorylated in platelets by thrombin stimulation [ 121], the phenotype of Vav1/Vav3−/− mice suggests Vav proteins do not mediate platelet function following PAR activation.

This was associated with a reduced priming effect of IGF-1 and IGF-2 on GPVI-mediated platelet function.

Furthermore, our observation that aspirin seemed to be partially protective suggests that part of the effect may be mediated by changes in platelet function.

The increased levels of VASP phosphorylation may directly inhibit platelet function mediated through the phosphorylation of myosin light chain kinase resulting in impaired calmodulin binding and therefore reduce cytoskeletal reorganization essential for platelet shape change (Onselaer et al., 2014).

The plasma form of FN circulates in the blood, and upon tissue injury, is incorporated into fibrin clots to exert effects on platelet function and to mediate hemostasis.

Clearly with such acute exposure, and as platelets have no nucleus, effects of PPARβ/δ agonists on platelet function must also be mediated independently of gene induction and the nucleus.

These IR/IGF1R heterodimers are thought to play a predominant role in mediating IGF-1s signalling in platelets and support of platelet function.

For instance, gelatinase B was found to process cytokines and chemokines, resulting in skewed immune functions (3, 4); while gelatinase A was reported to mediate platelet aggregation (5).

Changes in cognitive function, adherence to medications, nutritional status, inflammation, and platelet function will be explored as potential mechanisms by which depression may mediate poor outcomes.

Defects in platelet function, such as impaired adhesion or aggregation, are also primarily mediated by the integrin αIIbβ3.