Sentence examples for mediate platelet aggregation from inspiring English sources
Plasmin may mediate platelet aggregation through proteolytic cleavage of a thrombin receptor, protease-activated receptor 4 (PAR4) [ 12].
For instance, gelatinase B was found to process cytokines and chemokines, resulting in skewed immune functions (3, 4); while gelatinase A was reported to mediate platelet aggregation (5).
Interestingly, the locus vWF is the human marker HUMVWFA31 [60], a STR within the gene of von Willebrand factor, which is an adhesive plasma glycoprotein mediating platelet aggregation [105].
Hence, thrombin-mediated platelet aggregation and secretion are enhanced by complement components [1], most of them (C5, C6, C7, C8, C9 and, to a lesser extent, C3) being stored in platelets and secreted following activation [2], [3].
GP IIb/IIIa is the central platelet receptor mediating platelet aggregation.
The αIIbβ3 integrin is abundantly expressed on the surface of platelets and mediates platelet aggregation and adhesion.
These observations are consistent with other studies suggesting a critical role of the IgG Fc regions of anti-CD40L antibodies in mediating platelet aggregation [ 20].
8 This Gp IIb/ IIIa-mediated platelet aggregation has served as a target for antiplatelet therapy with Gp IIb/IIIa antagonists.
Therefore, it is possible that K-11 scFv exhibits antitumor activity against Aggrus-positive tumors by inhibiting Aggrus-mediated platelet aggregation.
(5) CD148 plays a vital role in mediating platelet aggregation under flow and in hemostasis and thrombus formation in vivo, with the latter being shown using 3 distinct models.
Upon activation, glycoprotein (Gp) IIb/IIIa (αIIbβ3 integrin) mediates platelet aggregation and spreading by means of fibrinogen bridges, which, once converted to fibrin, ultimately contribute to thrombus stabilization.
