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However, involvement of other signaling pathways that may recruit Akt to mediate other effects associated with bupivacaine cannot be ruled out.
The inability of fasudil to reverse pathogenesis of EMCV infection could imply that although NK-1R may be regulating Rho-A, it may mean that the Rho-A pathway may mediate other effects not related to the effects measured in this paper.
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We further observed a dramatic effect on the inhibition of migration in all assessed cell types, (Supplementary Figure 1b) suggesting that FAC can mediate other functional effects in ovarian cells.
Nonserotoninergic targets of fluoxetine that mediate its other effects are likely to have a lower binding affinity or lower availability for FLX.
Besides adhesion to collagen, α1 mediates several other effects, depending on cell type.
Our data are consistent with GSK3 acting via phosphorylating R2 and/or B, but could also be mediated via other effects of GSK3.
Nitric oxide is an inflammatory mediator that among other effects mediates cytoimmunity and inflammation toxicity.
It is true that efforts to delineate the potential synergistic role of methyl mercury and other chemicals in mediating neurocognitive and other effects are bedeviled by lack of knowledge about possible interactions and synergies among chemicals or between chemicals and other environmental hazards, even though the environment of a child includes mixtures of chemical and biologic toxicants.
ISG-encoded proteins mediate the antiviral and other effects of interferons.
Some of the effects of testosterone during this period are mediated by the androgen receptor, whereas other effects are mediated by oestrogen receptors, after local aromatisation of testosterone [ 2].
While there are a host of other effects mediated by proteasome inhibitors which can account for their activity in lymphoma, the accumulation of misfolded proteins and protein aggregates has been postulated to be among one of the more important mechanisms of cell death mediated by these drugs.
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