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Recognition of C-termini represents a form of non-invasive interaction well suited to mediate organization of transport, localization, sorting and spatial arrangement of proteins using their individual C-terminal tails recognized and handled by various PDZ domains.
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A study later shows functional differences between two substructures of CC; fan-shaped body mediates maintaining but not initiating movement, while ellipsoid body mediates organization of temporal locomotion pattern (Martin et al. 2001).
This result gives credence to the idea that SWI/SNF enzymes can mediate chromatin organization between specific loci on different chromosomes as well as regulate chromatin organization in response to external stimuli.
PTB domains bind both peptides and headgroups of phosphatidylinositides, utilizing two distinct binding motifs to mediate spatial organization and localization within cells.
The acidic phospholipid PA, a minor, dynamic component of the bilayer, does not bind to tubulins in vitro; instead, it may mediate microtubule organization by interacting with MAPs (Zhang et al., 2012).
Although PA does not bind to tubulins in vitro (Zhang et al., 2012), it may mediate cytoskeletal organization and dynamics by binding to and modulating cytoskeleton-associated proteins (Pleskot et al., 2013).
Moreover, other acidic phospholipids such as phosphatidylserine (PS), phosphatidylglycerol (PG), and phosphatidylinositol (PI) may also mediate cytoskeletal organization directly or regulate MAPs activity involved in microtubule arrays, but supporting evidence remains limited (Pleskot et al., 2013).
Changes in prefrontal activity during improvisation were accompanied by widespread activation of neocortical sensorimotor areas (that mediate the organization and execution of musical performance) as well as deactivation of limbic structures (that regulate motivation and emotional tone).
This first chromosomal-wide survey suggests that SARs and MARs work in concert to mediate genome organization and facilitate expression.
Although transfer of LTi-like cells into adult LTα−/− mice caused the expression of CCL21 and improved B- and T-cell segregation 29, it is not clear whether LTi-like cells are able to initiate secondary lymphoid tissue development or mediate the organization of B and T cells in developing tissue.
In addition to the mediation committees for labor disputes in businesses, 5 mediation organizations among grassroots and organizations that mediated disputes in towns and street offices were also allowed to mediate labor disputes.
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