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Substantial evidence suggests that distinct subpopulations of stem-like cells mediate many aspects of cancer biology, including metastasis and therapeutic resistance [59].
Rho GTPases mediate many aspects of cell biology including proliferation, regulation of the apoptosis/survival balance, polarity, adhesion, membrane trafficking and motility.
If the authors want to broaden the role of ghrelin acting on the 'hippocampus to orexin neuron circuit' to mediate many aspects a feeding, then they should compare the relative importance of hippocampal input to orexin neurons with other potential inputs (reviewer #2 comment 3).
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The amygdala plays a prominent role in mediating many aspects of emotional learning and behaviour.
The amygdala is part of the limbic system, a neural network that mediates many aspects of emotion and memory.
T cells, particularly CD4+ T helper (Th) cells, play a key role in mediating many aspects of autoimmune diseases.
Acute and repeated exposure to ethanol as well as to most other abused drugs increases dopamine (DA) levels in the mesolimbic region of the brain [4]; this brain region mediates many aspects of drug responding and reinforcement in a wide variety of behavioral paradigms [5].
T cells, in particular CD4+ T cells, have been implicated in mediating many aspects of autoimmune inflammation.
Phospholipases are critical enzymes involved in mediating many aspects of cellular function through modulating the physical properties of membranes, generation of lipid second messengers and cellular bioenergetics.
While it is acknowledged and accepted that chemical cues play a significant role in mediating many aspects of blowfly behaviour, the specific odours responsible are still to be elucidated.
Changes in reversible protein acetylation mediate many key aspects of genomic regulation and enzyme function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com