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To determine if the indirect pathway-specific regulatory cells can mediate linked suppression, CD4+ T cells were isolated from CBA mice given unmodified or virally transduced CBK DCs.
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T cells exposed to CTLA4-KDEL-expressing DCs in vivo also mediated linked suppression of fresh T cells, as shown by addition of irradiated CD4+CD25+ CBA T cells, from animals given virally transduced or control CBK DCs, to cultures in which (C57BL/6 × CBA F1 or (BALB/c × C57BL/6 F1 DCs were used to stimulate fresh CBA T cells (Fig. 5G and H).
However, current DNA-mediated linking mechanisms suffer from two shortcomings.
This work has proven to be informative about behavioral and brain mechanisms that mediate links between perceptual and motor processes invoked during the observation and execution of spatially temporally coordinated action and interpersonal interaction.
With caveat that we did not originally predict that initial academic adjustment would mediate links between social adjustment and the other outcomes, this pathway ultimately provided a two-step pathway of mediation from contact to social adjustment to academic adjustment and, finally, to the mid-year outcomes.
The job was once freighted with importance, a vital, mediating link between artist and audience.
Dissociation mediated links between inner speech and hallucination proneness.
Thus miR-278 has multiple functions, potentially including mediating links between nutrient availability and egg development.
Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival.
These pathological conditions were then related to functional descriptions (Gene Ontology terms) by using RefSeq annotations (RefSeq-NCBI) as mediating links, and the degree of relatedness were represented by 'GO-scores'.
Although previous studies suggest that the traditional Japanese dietary pattern is independently associated with a low cardiovascular disease mortality risk, the mechanisms mediating or linking this association are not well understood.
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