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ICL1 (TMD1–NBD1), ICL2 (TMD1–NBD2), ICL3 (TMD2–NBD2), and ICL4 (Tmediate2) mediate linkages between domains.
This cadre represents a unique human resource with the potential to mediate linkages between poorer women and healthcare.
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For instance, Dienstbier et al.[ 3] provide evidence that Egalitarian (EGL) and the dynein cofactor Bicaudal D (BICD), previously known to be required for minus-end-directed mRNA transport, mediate linkage of various mRNAs to the dynein motor in Drosophila melanogaster.
One can speculate that in a metastatic tumour microenvironment lacking many of the prostate-specific survival signals, E-cadherin-mediated linkages provide critical survival signals, by linking to both other carcinoma cells and even the hepatocytes themselves.
E2s are capable of mediating linkage specificity, either on their own, by the use of a cofactor or with the help of the respective substrate 6, 7.
The inability to obtain appointments during non-business hours when many patients present to the ED is a notable barrier we attempted to overcome through mediating linkage.
Here we show that FMRP is complexed with Bicaudal-D (BicD) through a domain in the latter protein that mediates linkage of cargoes with the minus-end-directed motor dynein.
Unexpectedly, the absence of DSBs in spo-11 rec-8 animals did not abrogate SCC in pachytene nuclei (6.8% lacking SCC), unlike in diakinesis nuclei (90% lacking SCC); however, we reasoned that axial element proteins and synaptonemal complex (SC) proteins might mediate the linkages that persist between sisters in pachytene nuclei of spo-11 rec-8 mutants and thereby obscure the role of DSBs.
Zirconium cations, a specific bridging agent, mediate the linkage between biotin modified phosphorylated peptides and ECL nanoprobes.
This is consistent with the need for glutamine or lysine side chains on the surface to which factor XIIIa can mediate covalent linkage.
Mutations of the proteins that mediate this linkage result in various types of hemolytic anemia.
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